NEW PERSPECTIVES ON MACROCYCLES FOR DRUG DISCOVERY
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Macrocycles for
Drug Discovery (MC4DD)

NEW PERSPECTIVES ON MACROCYCLES FOR DRUG DISCOVERY
​
Monday 28 February, 2022

Most welcome to watch the lectures of the symposium
Jan Kihlberg: Why (not) macrocycles in drug discovery?
Sereina Riniker: Polar/apolar interfaces in the permeation process of cyclic peptides
Felix Hausch: Natural product-inspired macrocycles for FK506-binding proteins
David Spring: Diverse Macrocycle Synthesis
Christian Heinis: Synthesis and screening of macrocyclic compound libraries at a nanomole-scale
Dehua Pei: Targeting intracellular protein-protein interactions with macrocyclic peptides
Mate Erdelyi: How to describe the solution conformations of macrocycles by NMR?
Carsten Kroll: Tethered Macrocyclic Peptides, a Novel Antibiotic Class Targeting Acinetobacter baumannii
Markus Schade: Macrocycles for Mcl1
Adrian Whitty: What makes a good bRo5 target
Sergey Ryabukhin

Scientific Program 

12:00 Welcome (Felix Hausch)
12:10 
Why (not) macrocycles in drug discovery?  (Jan Kihlberg)
12:30
Polar/apolar interfaces in the permeation process of cyclic peptides  (Sereina Riniker)
13:00 Diverse Macrocycle Synthesis (David Spring)
13:30  Natural product-inspired macrocycles for FK506-binding proteins (Felix Hausch)

14:00 Break

14:30 Synthesis and screening of macrocyclic compound libraries at a nanomole-scale (Christian Heinis)
15:00 Targeting intracellular protein-protein interactions with macrocyclic peptides (Dehua Pei)
15:30 How to describe the solution conformations of macrocycles by NMR? (Mate Erdelyi)

16:00 Break

16:30
Tethered Macrocyclic Peptides, a Novel Antibiotic Class Targeting Acinetobacter baumannii (Carsten Kroll)
17:00 Macrocycles for Mcl1 (Markus Schade)
​17:30 UORSY-enamine building block collection: an unexplored tool for expansion of macrocyclic chemical space Sergey Ryabukhin (UORSY)
​18:00 What makes a good bRo5 target (Adrian Whitty)
18:40 Concluding remarks

​
SPEAKERS
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David Spring
Department of Chemistry, University of Cambridge, UK

"Diversity-Oriented Synthesis of Macrocycles"
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Jan Kihlberg
Department of Chemistry - BMC, Uppsala University, Sweden
​

"Why (not) macrocycles in drug discovery"
Picture

Felix Hausch
Technical University Darmstadt,
​Germany


"Natural product-inspired macrocycles for FK506-binding proteins"
Picture
Adrian Whitty
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Sereina Riniker
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Christian Heinis
Department of Chemistry, Boston University, USA
"What makes a good bRo5 target"
Computational Chemistry, ETH Zürich, Switzerland
"Polar/Apolar Interfaces in the Permeation Process of Cyclic Peptides"
École polytechnique fédérale de Lausanne
​Lausanne, Switzerland​
"Synthesis and screening of macrocyclic compound libraries at a nanomole-scale"
Picture
Dehua Pei
Department of Chemistry and Biochemistry, Ohio State University, USA
"Targeting Intracellular Protein-Protein Interactions with Macrocyclic Peptides"
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Carsten Kroll
Roche Innovation Center Basel,
Switzerland​
"Tethered Macrocyclic Peptides, a Novel Antibiotic Class Targeting Acinetobacter baumannii​"
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Mate Erdelyi
Department of Chemistry - BMC, Uppsala University, Sweden
"Analyzing macrocycle conformations"
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Sergey Ryabukhin

UORSY,
Kiev, Ukraine
"UORSY-Enamine Building Block collection: an unexplored tool for expansion of macrocyclic chemical space."
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Markus Schade

AstraZeneca,
​Wilmslow, United Kingdom
"Macrocycles for Mcl1"
Registration deadline: February 27, 2022
All lectures will be broadcasted live via zoom.
Registration is free yet necessary to receive a zoom link and a password for virtual attendance. 
​

​Please register for the symposium here, 
the latest on February 27, 2022
​
Contact: Felix Hausch at [email protected]
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