NEW PERSPECTIVES ON MACROCYCLES FOR DRUG DISCOVERY
Monday 28 February, 2022
Most welcome to watch the lectures of the symposium
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Sergey Ryabukhin
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Scientific Program
12:00 Welcome (Felix Hausch)
12:10 Why (not) macrocycles in drug discovery? (Jan Kihlberg)
12:30 Polar/apolar interfaces in the permeation process of cyclic peptides (Sereina Riniker)
13:00 Diverse Macrocycle Synthesis (David Spring)
13:30 Natural product-inspired macrocycles for FK506-binding proteins (Felix Hausch)
14:00 Break
14:30 Synthesis and screening of macrocyclic compound libraries at a nanomole-scale (Christian Heinis)
15:00 Targeting intracellular protein-protein interactions with macrocyclic peptides (Dehua Pei)
15:30 How to describe the solution conformations of macrocycles by NMR? (Mate Erdelyi)
16:00 Break
16:30 Tethered Macrocyclic Peptides, a Novel Antibiotic Class Targeting Acinetobacter baumannii (Carsten Kroll)
17:00 Macrocycles for Mcl1 (Markus Schade)
17:30 UORSY-enamine building block collection: an unexplored tool for expansion of macrocyclic chemical space Sergey Ryabukhin (UORSY)
18:00 What makes a good bRo5 target (Adrian Whitty)
18:40 Concluding remarks
12:10 Why (not) macrocycles in drug discovery? (Jan Kihlberg)
12:30 Polar/apolar interfaces in the permeation process of cyclic peptides (Sereina Riniker)
13:00 Diverse Macrocycle Synthesis (David Spring)
13:30 Natural product-inspired macrocycles for FK506-binding proteins (Felix Hausch)
14:00 Break
14:30 Synthesis and screening of macrocyclic compound libraries at a nanomole-scale (Christian Heinis)
15:00 Targeting intracellular protein-protein interactions with macrocyclic peptides (Dehua Pei)
15:30 How to describe the solution conformations of macrocycles by NMR? (Mate Erdelyi)
16:00 Break
16:30 Tethered Macrocyclic Peptides, a Novel Antibiotic Class Targeting Acinetobacter baumannii (Carsten Kroll)
17:00 Macrocycles for Mcl1 (Markus Schade)
17:30 UORSY-enamine building block collection: an unexplored tool for expansion of macrocyclic chemical space Sergey Ryabukhin (UORSY)
18:00 What makes a good bRo5 target (Adrian Whitty)
18:40 Concluding remarks
Department of Chemistry, University of Cambridge, UK
"Diversity-Oriented Synthesis of Macrocycles" |
Department of Chemistry - BMC, Uppsala University, Sweden
"Why (not) macrocycles in drug discovery" |
Technical University Darmstadt,
Germany "Natural product-inspired macrocycles for FK506-binding proteins" |
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Department of Chemistry, Boston University, USA
"What makes a good bRo5 target"
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Computational Chemistry, ETH Zürich, Switzerland
"Polar/Apolar Interfaces in the Permeation Process of Cyclic Peptides"
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École polytechnique fédérale de Lausanne
Lausanne, Switzerland "Synthesis and screening of macrocyclic compound libraries at a nanomole-scale"
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Department of Chemistry and Biochemistry, Ohio State University, USA
"Targeting Intracellular Protein-Protein Interactions with Macrocyclic Peptides"
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Roche Innovation Center Basel,
Switzerland "Tethered Macrocyclic Peptides, a Novel Antibiotic Class Targeting Acinetobacter baumannii"
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Department of Chemistry - BMC, Uppsala University, Sweden
"Analyzing macrocycle conformations"
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Sergey RyabukhinUORSY,
Kiev, Ukraine "UORSY-Enamine Building Block collection: an unexplored tool for expansion of macrocyclic chemical space."
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Markus SchadeAstraZeneca,
Wilmslow, United Kingdom "Macrocycles for Mcl1"
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All lectures will be broadcasted live via zoom. Registration is free yet necessary to receive a zoom link and a password for virtual attendance. Please register for the symposium here, the latest on February 27, 2022 |